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. 2019 Mar 14;12:62. doi: 10.3389/fnmol.2019.00062

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Copyright © 2019 Wever, Largo-Barrientos, Hoekstra and Smidt.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Additional Lmx1b deletion partially rescues the cell loss observed in Pitx3 mutants alone. TH (green) and AHD2 (red) expression was assessed using immunohistochemistry in coronal midbrain sections of 3-month-old animals. (A) More TH+ cells were observed in lateral tier of the SNc (white arrows) and in the VTA (white arrowhead). The white dotted line represents the border between what is considered SNc and VTA. (B) Quantification of the total amount of TH+ cells shows an increase in TH+ cells of ~16% (n = 3, **P < 0.01, one-tailed). The number of TH+AHD2+ cells are not significant increased, but shows an upward trend (n = 3, P = 0.12, one-tailed). Pitx3CreCre; Lmx1b +/+ was set at 1. Scale bar = 100 μM.