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. 2019 Mar 14;12:62. doi: 10.3389/fnmol.2019.00062

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Copyright © 2019 Wever, Largo-Barrientos, Hoekstra and Smidt.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pitx3 driven deletion of Lmx1b results in a change in Aadc and Dat expression in the adult midbrain. Analysis of Th, Vmat2, Aadc and Dat in coronal adult section in the Pitx3Cre/+; Lmx1b L/L mutant via in situ hybridization. (A,B) Expression of Th and Vmat2 seem unaffected in Pitx3Cre/+; Lmx1b L/L animals, but the Pitx3 driven deletion of Lmx1b results in alteration in the expression of Aadc (C, arrowheads) and an overall reduction in Dat expression (D) in both rostral and caudal sections (arrowheads). Scale bar = 150 μM.