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. 2019 Mar 21;26:26. doi: 10.1186/s12929-019-0514-0

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — The OXTR mRNA levels and protein expressions in the mPFC, hippocampus, and amygdala. SPS reduced the OXT mRNA level in the mPFC, hippocampus, and amygdala, but only the mPFC OXTR mRNA level can be reversed by OXT administration (a-c). OXT reversed the SPS-decreased OXT protein expressions in the mPFC and amygdala, and these effects can be blocked by ASB (D, F). SPS and drugs (OXT and ASB) did not affect the hippocampus OXT protein expression (E). SPS = single prolonged stress, VEH = vehicle, OXT = oxytocin, ASB = atosiban, OXTR = oxytocin receptor. Bars represent mean ± SEM, *p < 0.05, **p < 0.01, ***p < 0.001, compared with Control-Veh; ##p < 0.01, ###p < 0.001, compared with Control-OXT; ^@p < 0.05, ^@@p < 0.01, ^@@@p < 0.001, compared with SPS-OXT. N = 5 for the mRNA levels (A-C); N = 4 for the protein expressions (d-f)