Table 2.
Summary of diagnostic criteria estimates and their 95% confidence intervals (95% CIs)
| Subgroup | SEN (95%CI) | SPE (95%CI) | PLR (95%CI) | NLR (95%CI) | DOR (95%CI) |
|---|---|---|---|---|---|
| Type | |||||
| Pro | 0.92 (0.89, 0.94) | 0.59 (0.49, 0.68) | 2.26 (1.89, 2.70) | 0.10 (0.06, 0.15) | 21.12 (12.83, 34.76) |
| Retro | 0.73 (0.65, 0.79) | 0.65 (0.55, 0.74) | 1.98 (1.60, 2.45) | 0.32 (0.23, 0.47) | 5.88 (3.73, 9.28) |
| Ethnicity | |||||
| Asian | 0.81 (0.74, 0.86) | 0.64 (0.53, 0.74) | 2.23 (1.71, 2.93) | 0.23 (0.15, 0.35) | 9.31 (5.03, 17.23) |
| Caucasian | 0.89 (0.84, 0.92) | 0.60 (0.51, 0.69) | 2.16 (1.83, 2.55) | 0.13 (0.08, 0.20) | 15.28 (9.45, 24.68) |
| miRNA profiling | |||||
| Single miRNA | 0.86 (0.81, 0.89) | 0.59 (0.51, 0.66) | 2.02 (1.79, 2.33) | 0.17 (0.12, 0.26) | 11.11 (7.55, 16.34) |
| Multiple miRNA | 0.90 (0.75, 0.97) | 0.74 (0.59, 0.85) | 3.21 (2.06, 5.01) | 0.09 (0.03, 0.28) | 30.06 (8.58, 105.37) |
| miRNA 200 family | 0.90 (0.80, 0.95) | 0.58 (0.43, 0.72) | 1.98 (1.61, 2.44) | 0.11 (0.07, 0.17) | 15.48 (7.15, 33.51) |
| miRNA 200c | 0.85 (0.67, 0.94) | 0.52 (0.22, 0.81) | 1.88 (1.17, 3.03) | 0.19 (0.06, 0.57) | 8.84 (3.20, 24.40) |
| overall | 0.89 (0.84, 0.93) | 0.64 (0.56, 0.72) | 2.18 (1.90, 2.51) | 0.15 (0.11, 0.22) | 13.21 (9.00, 19.38) |
SEN sensitivity, SPE specificity, PLR positive likelihood ratio, NLR negative likelihood ratio, DOR diagnostic odds ratio, miRNA microRNA, Pro prospective, Retro retrospective.