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. Author manuscript; available in PMC: 2020 Mar 14.
Published in final edited form as: J Med Chem. 2019 Feb 21;62(5):2564–2581. doi: 10.1021/acs.jmedchem.8b01878

Figure 6.

Figure 6.

Effects of MK-4, UP, HMBPP and FPP as well as pairwise combinations on B. subtilis growth inhibition by 74. (a) Effects of MK-4, UP and MK-4 plus UP on growth inhibition by 74. (b) Effects of HMBPP, FPP with or without MK-4 or UP as well as HMBPP+FPP on 74 inhibition of B. subtilis cell growth. All rescue agents were at 50 µM. (c) Schematic illustration of the x-fold rescues by compounds or pairs of compounds on B. subtilis growth inhibition by 74. The largest effect (25x) is found with UP (50 µM) + MK-4 (50 µM). Cell growth inhibition assays were carried out in duplicate. The largest effects (~>9x) are seen with MK-4 or UP combinations and are colored cyan. d) Summary of IC50 values from data in a) and b).