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. Author manuscript; available in PMC: 2019 Nov 1.
Published in final edited form as: J Knee Surg. 2018 Sep 7;31(10):928–933. doi: 10.1055/s-0038-1669915

Table 4.

Causes for revision total knee arthroplasty by drug abuse or dependency

Cause Rev Cocaine Cannabis Opioid SHA Amphetamines Alcohol
Mechanical
loosening
23,563 9.5% 214 8.7% 259 10.6% 1,065 11.0% 247 10.5% 66 9.7% 1,139 9.4%
Failure/break 7,093 2.9% 60 2.4% 69 2.8% 360 3.7% 82 3.5% 19 2.8% 351 2.9%
Periprosthetic
fracture
3,457 1.4% 29 1.2% 32 1.3% 199 2.1% 51 2.2% 11 1.6% 200 1.6%
Osteolysis 1,860 0.7% 15 0.6% 18 0.7% 87 0.9% 18 0.8% <11 N/A 78 0.6%
Infection 39,385 15.9% 441 17.9% 547 22.5% 2,107 21.8% 462 19.6% 161 23.8% 2,535 20.9%
Pain-joint
replacement
29,667 12.0% 328 13.3% 363 14.9% 1,502 15.5% 363 15.4% 102 15.1% 1,509 12.4%
Arthrofibrosis 7,204 2.9% 87 3.5% 81 3.3% 344 3.6% 70 3.0% 19 2.8% 335 2.8%
Instability 3,999 1.6% 49 2.0% 70 2.9% 269 2.8% 72 3.1% 17 2.5% 263 2.2%
Trauma 1,224 0.5% 42 1.7% 53 2.2% 144 1.5% 43 1.8% 18 2.7% 141 1.2%

Abbreviation: SHA, sedatives/hypnotics/anxiolytics.