Table 7.
Effect of KEKS food on IP indomethacin plus lipopolysaccharide-evoked changes in SWD number on the 9th KEKS day (9K+I+L; Figure 5, group 6).
| Treatments (Figure 5; group 6) | SWD number (mean ± S.E.M.; significance level/p-value) | |
|---|---|---|
| 30–90 min | 90–150 min | |
| Control (CON) | 19.7 ± 0.783 | 17.9 ± 0.508 |
| 1st KEKS treatment (1K) | 19.1 ± 4.223 –/>0.9999 | 18.3 ± 2.631 –/>0.9999 |
| 2nd KEKS treatment (2K) | 15.1 ± 2.191 –/0.9819 | 17.3 ± 1.521 –/>0.9999 |
| 3rd KEKS treatment (3K) | 13.6 ± 2.964 –/0.7755 | 15.4 ± 2.375 –/>0.9999 |
| 4th KEKS treatment (4K) | 12.0 ± 2.435 –/0.3315 | 12.8 ± 1.770 –/0.9261 |
| 5th KEKS treatment (5K) | 11.8 ± 2.194 –/0.3626 | 12.7 ± 1.129 –/0.9261 |
| 6th KEKS treatment (6K) | 8.4 ± 1.752 **/0.0059 | 8.4 ± 0.653 */0.0396 |
| 7th KEKS treatment (7K) | 6.0 ± 1.069 ***/0.0001 | 8.0 ± 0.378 */0.0335 |
| 8th KEKS treatment (8K) | 7.4 ± 1.017 **/0.0014 | 8.1 ± 0.598 */0.0335 |
| 9th KEKS + indomethacin + LPS treatment (9K+I+L) | 6.6 ± 1.426 ***/0.0004 | 9.6 ± 1.700 –/0.0794 |
| 10th KEKS treatment (10K) | 5.6 ± 1.238 ****/<0.0001 | 7.6 ± 2.138 **/0.0077 |
1st KEKS treatment, 1st day of KEKS food administration; LPS, lipopolysaccharide; SWD, spike-wave discharge.
*
p < 0.05,
**
p < 0.01,
***
p < 0.001, and
****
p < 0.0001.