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. 2019 Mar 14;10:156. doi: 10.3389/fendo.2019.00156

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Copyright © 2019 Lazcano, Rodríguez-Ortiz, Villalobos, Martínez-Torres, Solís-Saínz and Orozco.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Characterization of thrab and l-thrb^* crispants. (A) thrab crispants do not show effects upon zebrafish morphology, whereas l-thrb^* crispants generated with an sgRNA able to target all thrb isoforms showed a low percentage of affected phenotypes characterized by laterality. (B,C) Represent the percentage of normal, affected and deceased larvae after sgRNA and Cas9 treatment. (D) The DNA sequence of sgRNA target site for CRISPR/Cas9 is denoted in gray, whereas PAM sequence is denoted in blue. Insertion-deletions (indels) are highlighted in yellow.