Fig. 5. (A) Schematic illustration of the XOR gate. (B) Normalized fluorescence spectra generated by the XOR gate. Inset: the bar representation and Truth table of the XOR logic gate system. (C) Living cell analysis of different cell lines using the designed XOR logic gate to trace intracellular miRNAs in (a) MRC-5, (b) A549, (c) MCF-7, and (d) MDA-MB-231. All scale bars correspond to 20 μm. (D) Statistical histogram analysis of the relative fluorescence intensity (FRET/FAM) of the above four different cell lines using the endogenous miRNA-initiated XOR gate.
