Scheme 1. Biosynthesis of ashimides. (A) The asm gene cluster and schematic comparison of asm neighbouring genes in S. sp. NA03103 with their homologs in S. lividans TK24; (B) proposed biosynthetic pathway of ashimides A and B; (C) proposed biosynthetic pathway of the benzoxazolinate moiety in ashimides. mTHF, 5,10-methylenetetrahydrofolate; THF, tetrahydrofolate; ADIC, 2-amino-2-desoxyisochorismate; OPA, 3-enolpyruvoylanthranilate.
