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. 2019 Mar 20;2(2):e201800262. doi: 10.26508/lsa.201800262

Figure S8. PDK4 expression is induced in Tg mice by pemafibrate although a decrease in PPARs is observed.

Figure S8.

(A) Comparative RT-qPCR analyses of Pdk4 mRNA levels in the hippocampus of transgenic (Tg) 5xFAD mice treated at 12 mo with the PPARα agonist pemafibrate (pema) (1 mg/kg/d, Tg + pema; n = 12) or vehicle (Tg + veh; n = 8) (water 0.1% Tween 80, Tg + veh) by gavage (12 d). Results were normalized to Gapdh mRNA and are expressed as percentage of Tg + veh (**P < 0.01, t test). (B) Comparative RT-qPCR analyses of Ppara, Pparb, and Pparg (encoding PPARα, PPARβ, and PPARγ, respectively) mRNA levels in the hippocampus of transgenic (Tg) 5xFAD and age-matched control non-transgenic wild-type (Wt) mice at 9–10 mo (n = 4 of each). Results were normalized to Gapdh mRNA and are expressed as percentage of corresponding non-Tg (**P < 0.01, *P < 0.05, t test). Data information: data are presented as mean ± SEM.