Table 2. Regional binding values of 18F-THK5351 PET in NC, AD, and navPPA patients.
| Regions | 18F-THK5351 SUVR | |||||
|---|---|---|---|---|---|---|
| NC | AD | navPPA | ||||
| Mean (SD) | Mean (SD) | Z-score | Mean (SD) | Z-score | ||
| Precentral | ||||||
| Left | 0.93 (0.16) | 1.37 (0.22) | 2.75 | 2.16 (0.16) | 7.69 | |
| Right | 0.84 (0.18) | 1.18 (0.22) | 1.89 | 1.33 (0.23) | 2.72 | |
| Inferior frontal | ||||||
| Left | 1.21 (0.22) | 1.86 (0.24) | 2.95 | 1.85 (0.36) | 2.91 | |
| Right | 1.20 (0.19) | 1.81 (0.32) | 3.21 | 1.75 (0.45) | 2.89 | |
| Broca area | ||||||
| Left | 1.11 (0.24) | 1.80 (0.24) | 2.88 | 1.93 (0.45) | 3.42 | |
| Lateral temporal | ||||||
| Left | 1.42 (0.18) | 2.34 (0.24) | 5.11 | 1.80 (0.21) | 2.11 | |
| Right | 1.36 (0.14) | 2.36 (0.43) | 5.56 | 1.71 (0.20) | 1.94 | |
| Mesial temporal | ||||||
| Left | 2.50 (0.25) | 3.03 (0.68) | 2.12 | 2.90 (0.24) | 1.60 | |
| Right | 2.57 (0.23) | 3.01 (0.61) | 1.91 | 2.75 (0.24) | 0.78 | |
| Fusiform | ||||||
| Left | 1.62 (0.18) | 2.25 (0.39) | 3.59 | 2.02 (0.20) | 2.22 | |
| Right | 1.62 (0.22) | 2.28 (0.41) | 3.00 | 2.04 (0.31) | 1.91 | |
| Superior parietal | ||||||
| Left | 1.16 (0.24) | 2.05 (0.49) | 3.71 | 1.64 (0.56) | 2.00 | |
| Right | 1.11 (0.26) | 2.21 (0.48) | 4.23 | 1.52 (0.16) | 1.58 | |
| Inferior parietal | ||||||
| Left | 1.34 (0.18) | 2.29 (0.39) | 5.28 | 1.83 (0.35) | 2.72 | |
| Right | 1.25 (0.14) | 2.37 (0.61) | 8.00 | 1.47 (0.90) | 1.57 | |
| Insula | ||||||
| Left | 1.67 (0.19) | 2.42 (0.26) | 3.95 | 2.13 (0.50) | 2.42 | |
| Right | 1.71 (0.22) | 2.52 (0.22) | 3.68 | 2.23 (0.70) | 2.36 | |
| Anterior cingulate | ||||||
| Left | 1.93 (0.21) | 2.45 (0.40) | 2.48 | 2.36 (0.52) | 2.05 | |
| Right | 1.76 (0.23) | 2.35 (0.41) | 2.57 | 2.31 (0.62) | 2.39 | |
| Posterior cingulate | ||||||
| Left | 1.40 (0.17) | 2.27 (0.28) | 5.12 | 1.77 (0.29) | 2.18 | |
| Right | 1.33 (0.18) | 2.30 (0.41) | 5.39 | 1.55 (0.15) | 1.22 | |
| Occipital | ||||||
| Left | 1.18 (0.15) | 1.83 (0.34) | 4.33 | 1.46 (0.36) | 1.87 | |
| Right | 1.18 (0.13) | 1.90 (0.43) | 5.54 | 1.47 (0.33) | 2.23 | |
| Basal ganglia | ||||||
| Left | 2.45 (0.40) | 2.66 (0.33) | 0.52 | 3.59 (0.88) | 2.85 | |
| Right | 2.30 (0.36) | 2.54 (0.33) | 0.67 | 3.64 (0.47) | 3.72 | |
| Brainstem | 2.17 (0.24) | 2.20 (0.37) | 0.13 | 2.68 (0.49) | 2.13 | |
PET: positron emission tomography, NC: normal control, AD: Alzheimer's disease, navPPA: nonfluent/agrammatic variant primary progressive aphasia, SUVR: standardized uptake value ratio, SD: standard deviation.