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. 2019 Mar 14;10:459. doi: 10.3389/fimmu.2019.00459

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Copyright © 2019 Abo, Flannigan, Geem, Ngo, Harusato and Denning.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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IL-2/JES6-1 immunocomplexes induce colonic Foxp3+ Treg accumulation during DSS-induced intestinal inflammation. WT mice were treated with 3% DSS in drinking water. At day 6, DSS water was replaced with normal water. IL-2/JES6-1 immunocomplexes were delivered every 2 days. CD4⁺Foxp3⁺Treg cells were analyzed by flow cytometry. Representative dot plots are shown in (A). Frequency of CD4⁺Foxp3⁺ T cells are shown in (A) and total cell numbers of CD4+Foxp3+T cells are shown in (B). (C) Expression of the Treg-related genes, Foxp3, Cd25, and Ctla4 were analyzed by qPCR using total colonic tissue. Data are representative of two independent experiments with 4–6 mice/group. All data are presented as mean ± SEM; *P < 0.05, **P < 0.01, ***P < 0.001, one-way ANOVA with Tukey's multiple comparison test.