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. 2019 Mar 14;10:459. doi: 10.3389/fimmu.2019.00459

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Copyright © 2019 Abo, Flannigan, Geem, Ngo, Harusato and Denning.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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IL-2/JES6-1 immunocomplex administration promotes intestinal ILC2 expansion and IL-5 expression. WT mice were treated with 3% DSS for 6 days and received normal water thereafter. IL-2/JES6-1 immunocomplexes were delivered every 2 days. IL-5 mRNA expression in total colon tissue was analyzed by quantitative real-time PCR (A). LPL from each mouse were restimulated by PMA/ionomycin and ILC2 cells were analyzed by flow cytometry. Represent dot plots are shown in (B) and the frequency and total cell numbers are shown in (C) after pre-gating on live, lin- cells. IL-5+ILC2 were analyzed by flow cytometry (D). Data are representative of two independent experiments with 4–6 mice/group. All data are presented as mean ± SEM; *P < 0.05, ***P < 0.001, one-way ANOVA with Tukey's multiple comparison test.