Table 1:
Baseline Characteristics of Adolescents with and without T1D with Baseline Aortic MRI Data
| Variables | T1D (n = 37) | Controls (n = 24) | p-value |
|---|---|---|---|
| Age (years) | 16.8 ± 2.6 | 15.6 ± 2.6 | 0.10 |
| Sex (% female) | 46% | 54% | 0.53 |
| BMI Z-score | 0.95 ± 1.01 | 0.34 ± 0.74 | 0.01 |
| Diabetes duration (years) | 7.8 ± 4.2 | -- | -- |
| HbA1c (mmol/mol) | 72 ± 9.4 | -- | -- |
| SBP (mmHg) | 122 ± 9 | 114 ± 9 | 0.002 |
| DPB (mmHg) | 72 ± 8 | 67 ± 7 | 0.02 |
| SBP percentile | 72 ± 25 | 64 ± 22 | 0.20 |
| DBP percentile | 67 ± 21 | 56 ± 18 | 0.17 |
| Heart rate (BPM) | 71 ± 10 | 71 ± 15 | 0.97 |
| MRI Measures | |||
| AA WSSMAX (dyne/cm2)* | 10.9 ± 0.4 | 8.7 ± 0.5 | 0.002 |
| AAWSSTA (dyne/cm2)* | 2.7 ± 0.1 | 1.9 ± 0.1 | < 0.001 |
| AA PWV (m/s)* | 3.7 ± 0.3 | 2.5 ± 0.4 | 0.045 |
| AA RAC (%) | 27 ± 5 | 30 ± 5 | 0.002 |
| DA WSSMAX (dyne/cm2)* | 15.5 ± 0.6 | 10.7 ± 0.7 | < 0.001 |
| DA WSSTA (dyne/cm2)* | 4.1 ± 0.1 | 2.7 ± 0.2 | < 0.001 |
| DA PWV (m/s)* | 4.2 ± 0.2 | 3.1 ± 0.3 | 0.02 |
| DA RAC (%) | 22 ± 4 | 26 ± 6 | 0.01 |
Limited to participants who had phase-contrast MRI data at baseline. Data are n (%), means ± SD unless otherwise noted.
*
Sex, age and BMI percentile adjusted means presented as least square means ± SEM
BMI = body mass index, SBP =systolic blood pressure, DBP =diastolic blood pressure, BPM=beats per minute, WSSMAX = maximal wall shear-stress, WSSTA = time-averaged wall shear-stress, PWV =pulse wave velocity, RAC = relative area change