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. Author manuscript; available in PMC: 2019 Jun 14.
Published in final edited form as: J Med Chem. 2018 May 16;61(11):4860–4882. doi: 10.1021/acs.jmedchem.8b00168

Scheme 4:

Scheme 4:

a) NH4Cl, HATU, DIPEA, DMF, rt, 1 h, 80–99%; b) (CF3CO)2O, Et3N, DCM, 0 °C to rt, 1 h, 64–76%; c) TMSOTf, anisole, μW, 140 °C, 1 h, 80%; d) CuSO45H2O, NaN3, DMSO, 140 °C, 6 h, 69–99%; e) TFA, rt, 10 min; 44–74%.