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. Author manuscript; available in PMC: 2019 Sep 1.
Published in final edited form as: Curr Opin Biomed Eng. 2018 Oct 9;7:71–82. doi: 10.1016/j.cobme.2018.10.002

Figure 4:

Figure 4:

Schematic diagram of gene delivery using RPM-conjugated bioreducible gene carriers (SSbPEI-PEG-RPM) (Reproduced from reference [22], with permission from Elsevier). In this work, α5β1 integrin receptor-overexpressing invasive colon cancer cells (HT29) interacted with RPM peptides to enhance receptor-mediated endocytosis of the PEGylated polyplexes. Enhanced uptake was not observed in non-invasive colon cancer cells (HCT116). Following endosomal escape through the proton sponge effect of PEI, released pDNA was successfully transfected into the nucleus. IR820 was used for infrared imaging in transfected cells.