Table 6. Cox regression multivariate analysis for overall survival in octogenarian with hepatocellular carcinoma.
| Variables | Univariate | Multivariate | |||||
| Median survival (months)a | p value | Hazard ratio (95% CI) | p value | ||||
| Gender (male vs. female) | 52.9 ± 17.5 vs. 57.4 ± 10.7 | 0.871 | |||||
| Comorbidity (yes vs. no) | 52.9 ± 7.8 vs. 37.6 ± 28.6 | 0.686 | |||||
| Hepatitis B virus (yes vs. no) | 57.4 ± 27.9 vs. 50.2 ± 21.4 | 0.472 | |||||
| Hepatitis C virus (yes vs. no) | 42.4 ± 16.7 vs. 92.4 ± 15.3 | 0.259 | |||||
| á-fetoprotein ≥ 400ng/mL (yes vs. no) | 14.1 ± 23.5 vs. 71.5 ± 14.4 | 0.011 | 2.235 (1.09 ~ 4.57) | 0.028 | |||
| Surgical complications (yes vs. no) | 57.8 ± 6.8 vs. 59.9 ± 7.8 | 0.489 | |||||
| Tumor size ≥ 10cm(yes vs. no) | 11.3 ± 13.3 vs. 57.4 ± 13.5 | 0.040 | 2.304 (1.04 ~ 5.12) | 0.041 | |||
| Encapsulation (yes vs. no) | 50.2 ± 7.5 vs. 92.4 ± 57.5 | 0.677 | |||||
| Tumor rupture (yes vs. no) | 7.4 ± 9.6 vs. 69.9 ± 12.5 | 0.001 | 2.088 (0.79~ 5.51) | 0.137 | |||
| Vascular invasion (yes vs. no) | 37.6 ± 14.5 vs. 102 ± 22 | 0.002 | 2.301 (1.09 ~ 4.88) | 0.030 | |||
| Daughter nodules (yes vs. no) | 57.3 ± 12.8 vs. 45 ± 15.4 | 0.286 | |||||
| Resection margin (positive vs. negative) | 3.3 ± 1.3 vs. 57.4± 12.7 | 0.135 | |||||
| Edmondson-Steiner grade (I /II vs. III/IV) | 69.9 ± 18.1 vs. 57.4± 15.4 | 0.514 | |||||
| Cirrhosis (yes vs. no) | 57.4 ± 9.6 vs. 50.2 ± 17 | 0.831 | |||||
a: median ±standard error of median.