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. 2019 Mar 11;11(5):1427–1439. doi: 10.18632/aging.101843

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Copyright © 2019 Ni et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY) 3.0 License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MiR-185-5p targets HMGA2. (A) The binding site of miR-185-5p in the 3’UTR of HMGA2 was predicted via TargetScan. (B) Correlation between HMGA2 and miR-185-5p was validated in a luciferase reporter assay. (C, D) Protein and mRNA expression of HMGA2 after transfection with miR-185-5p mimic in U251 cells were analyzed by Western blot and qRT-PCR, respectively. (E-H) Effects of the FOXD2-AS1/miR-185-5p axis on HMGA2 protein (E, F) and mRNA (G, H) expression were analyzed by Western blot and qRT-PCR, respectively. **p < 0.01 vs. Control; ^##p < 0.01 vs. NC; ^&&p < 0.01 vs. si-FOXD2-AS1.