Table 1. Clinical features of NSCLC patients with sequence results of IRS1 gene (SCC: Squamous cell carcinoma, ADC: Adenocarcinoma, LCC:Large cell carcinoma, ADC: Adenosquamous carcinoma ; M: Male, F:Female, WT: Wild Type).

Patients Number	Gender	Age	Tumor type	Tumor size	TNM	Stage	Sequencing result
2	M	54	SCC	8 cm	T2N0M0	1b	WT
3	M	56	ASC	8 cm	T2N1M0	2a	WT
7	M	48	ASC	11 cm	T2N1M0	2b	WT
8	M	66	SCC	10 cm	T2N0M0	1b	WT
9	M	47	SCC	2 cm	T2N1M0	2b	WT
11	M	69	SCC	8.5 cm	T2N1M0	2b	rs138975702
13	M	67	SCC	4 cm	T3N0M0	2b	p.S668T
14	M	53	SCC	8 cm	T2N0M0	1b	WT
15	M	79	SCC	2 cm	T2N0M0	1b	WT
16	M	65	SCC	9 cm	T2N1M0	2b	p.S668T, p.D674H
18	F	69	SCC	3.5 cm	T2N1M0	2b	WT
19	M	56	ASC	7.5 cm	T2N0M0	1b	p.S668T, p.A642S
22	M	77	SCC	6 cm	T2N2M0	3a	WT
24	M	50	SCC	6 cm	T2N0M0	1b	WT
25	M	67	SCC	5 cm	T2N1M0	2b	WT
26	M	67	ASC	5 cm	T2N0M0	1b	p.S668T, H599A
27	M	68	LCC	2 cm	T1N1M0	2a	p.S668T
28	M	71	ADC	9 cm	T2N1M0	2b	WT
30	M	58	ASC	6.5 cm	T2N0M0	1b	WT
31	M	60	ASC	5 cm	T2N0M0	1b	WT
32	M	62	SCC	8.5 cm	T2N0M0	1b	WT
33	M	65	ASC	9.5 cm	T3N0M0	2b	rs138975702
34	M	62	SCC	2 cm	T1N0M0	1a	rs143032259
36	M	57	SCC	7 cm	T2N0M0	1b	WT
37	M	62	SCC	8.5 cm	T2N1M0	2b	WT
38	M	51	SCC	3 cm	T2N1M0	2b	WT
40	M	45	SCC	5.5 cm	T2N0M0	1b	p.S668T, p.D674H
42	M	57	SCC	6 cm	T2N0M0	1b	p.S668T, p.D674H, p.A642S
43	M	59	ADC	3.2 cm	T3N1M0	3a	WT
44	M	68	SCC	3.8 cm	T2N0M0	1b	WT
46	M	71	SCC	6.5 cm	T1N0M0	1a	WT
47	M	67	SCC	4 cm	T2N1M0	2b	p.S668T, p.D674H
49	M	54	SCC	3.5 cm	T2N1M0	2b	WT
53	M	68	SCC	4.2 cm	T3N0M0	2b	WT
55	M	59	SCC	2.5 cm	T1N0M0	1a	WT
56	M	55	SCC	4.5 cm	T2N1M0	2b	WT
58	M	61	ADC	2.5 cm	T2N0M0	1b	WT
59	M	54	ADC	5 cm	T2N0M0	1b	WT
60	M	63	SCC	2.5 cm	T2N1M0	2b	p.S668T
61	M	60	SCC	3.8 cm	T2N0M0	1b	WT
62	M	39	ADC	4 cm	T2N0M0	1b	WT
63	M	63	SCC	3 cm	T2N1M0	2b	rs138975702