Figure 4 . Tumor stage-dependent gene expression. (A and C) Shown is the increase in expression of Synaptobrein2 and Syntaxin1A in a tumor stage-dependent manner (lowest in I and highest in III). (B) A significant difference in the expression of Synaptobrevin2 is seen between stages I and II, and stages I and III, whereas no difference is observed between stage II and III. (D) A significant difference is seen in the expression of Syntaxin1A between stages I and II, and stages I and III, whereas no difference is observed between stages II and III.