Table 4. List of differentially expressed genes in ME/CFS patients compared to controls.

Comparison	Gene ID	Gene name	Fold change	FDR	Gene count (avg.)
ME/CFS vs controls; all days	HOXA9	Homeobox A9	2.57	0.08	0.37
	LOC101928767	Uncharacterized	2.03	0.08	1.92
	NRON	Noncoding Repressor Of NFAT	1.53	0.08	0.36
	RPL23A	Ribosomal Protein L23a	-1.77	0.06	39.63
	RPS12	Ribosomal Protein S12	-1.56	0.02	646.28
	SNORA27	Small Nucleolar RNA, H/ACA Box 27	6.35	0.06	50.88
ME/CFS vs controls; Day 7	LINC01158	Long Intergenic Non-Protein Coding RNA 1158	1054	0.10	0.11
Lower ${\dot{\text{V}}\text{O}}_2$ vs Normal ${\dot{\text{V}}\text{O}}_2$; Day 1	LOC105372441	Uncharacterized	5745	3.72E-04	0.12
Lower ${\dot{\text{V}}\text{O}}_2$ vs Normal ${\dot{\text{V}}\text{O}}_2$; Day 2	LOC100133050	Glucuronidase Beta Pseudogene	6.42	1.19E-03	0.01
	PMS2P2	PMS1 Homolog 2, Mismatch Repair System Component Pseudogene 2	813	0.05	0.01
Lower ${\dot{\text{V}}\text{O}}_2$ vs Normal ${\dot{\text{V}}\text{O}}_2$; Day 7	PRR21	Proline Rich Protein 21	2072	1.98E-03	0.04
	TMEM262	Transmembrane Protein 262	11.07	1.98E-03	0.16
	USP50	Ubiquitin Specific Peptidase 50	1979	6.86E-03	0.04
Test-retest effect vs Regular exercise; Day 2	MBIP	MAP3K12 Binding Inhibitory Protein 1	-1.94	0.1	3.28
	SNORA32	Small Nucleolar RNA, H/ACA Box 32	726520	0.04	5.24
Test-retest effect vs Regular exercise; Day 3	LOC100133050	Glucuronidase Beta Pseudogene	4.7	0.04	0.01
	PMS2P2	PMS1 Homolog 2, Mismatch Repair System Component Pseudogene 2	947.93	4.81E-03	0.01
	RNASE8	Ribonuclease A Family Member 8	7956	0.04	0.12
Test-retest effect vs Regular exercise; Day 7	CREB3L1	CAMP Responsive Element Binding Protein 3 Like 1	5.82	0.04	0.04
	HNF4A-AS1	HNF4A Antisense RNA 1	2293	0.03	0.03
	LINC01068	Long Intergenic Non-Protein Coding RNA 1068	20.41	0.04	0.14
	TMEM262	Transmembrane Protein 262	14.06	1.19E-05	0.16