Table 1. LD50 values from Micrurus venoms studied herein, compared with literature data.
Micrurus species | |||||||
---|---|---|---|---|---|---|---|
Source | dumerilii | mipartitus | isozonus | surinamensis | medemi | lemniscatus | spixii |
This study | 23.72 | 33.62 | 6.29 | 29.17 | 8.79 | 22.87 | 13.89 |
(18.09–31.12) | (26.15–43.22) | (5.14–7.69) | (24.42–34.84) | (7.16–10.80) | (17.79–29.4) | (N.D.) | |
Bolaños et al. [37] | 17.00 | - | - | 5−10 | - | 5* | 10−15* |
(N.S.) | (N.S.) | (N.S.) | (N.S.) | ||||
Tanaka et al.[16] | - | - | 58** | - | 13** | 8** | |
(43–87) | (7–22) | (6–16) | |||||
Silva[38] | - | - | 9.43 | - | 10.12 | 50.6 | |
(N.S.) | (N.S.) | (N.S.) | |||||
Cohen [14] | 16.3 | - | - | - | - | - | 27.3*** |
(N.S.) | (N.S.) | ||||||
Cohen[13] | 11.9 | - | - | - | - | - | - |
(N.S.) | |||||||
Rey-Suarez et al. [23] | 22.42 | - | - | - | - | - | - |
(14.5–36–1) | |||||||
Otero et al. [39] | - | 9 | - | - | - | - | - |
(6.6–9.1) | |||||||
Oliveira et al. [40] | - | - | - | 14** | - | - | - |
(11.3–16.8) | |||||||
de Roodt et al. [26] | - | - | - | 7.6 | - | - | - |
(5–19) | |||||||
de Roodt et al. [41] | - | - | - | 20 | - | - | - |
(N.S.) | |||||||
Salazar et al. [42] | - | - | 11.4 | - | - | - | - |
(N.S.) | |||||||
Higashi et al. [15] | - | - | - | - | - | - | 6.7** |
(N.S.) | |||||||
Max/Min ratio | 1.99 | 3.74 | 1.81 | 11.60 | - | 4.57 | 7.55 |
Values are given in μg/mice (see Materials and Methods for details). 95% confidence intervals are indicated in parenthesis. N.D., not determined because, on the trial doses, only death ratios corresponding to 0% and 100% were recorded; N.S., not specified on the study. Data without asterisk marks correspond to venoms from Colombia;
*unknown origin;
** Brazil;
*** Peru.