Table 3. Comparative ED₅₀^a values of the coral snake antivenoms distributed in South America, against venoms of the species studied herein.

		Micrurus species venom
Producer	Sourceb, c	dumerilii	mipartitus	isozonus	surinamensis	medemi	lemniscatus	spixii
INS	This study	3.6	9.4	22.4	3.1	6.8	5.8	15.8
		(151.77)	(279.6)	(3561.21)	(106.27)	(773.61)	(253.61)	(1137.51)
ICP	Rey Suarez et al. [23,47]	2	none	-	-	-	-	-
		(89.21)
Bioclon	de Roodt et al. [26]	-	-	-	<0.3	-	-	-
					(<39.47)
IB	Ramos et al. [29]	-	-	-	-	-	noned	noned
	Tanaka et al. [16]	-	-	-	-	-	0.7	5
							(53.85)e	(625)e
	Tanaka et al. [44]	-	-	-	-	-	0.7	3.7
							(53.85) e	(462.50) e
INPBA	de Roodt et al. [26]	-	-	-	4.22	-	-	-
					(555.26)

^a ED₅₀ is given as mg/10 mL vial (#LD50 [μg/mice]/ 10 mL vial).

^b All studies challenged antivenoms against 3 LD₅₀ except Tanaka et al. [16,44] who used 2 LD₅₀.

^c In all studies mixtures of venom and antivenom were injected intraperitoneally.

^d No ED₅₀ was estimated, only ratio of survival from one trial.

^e Values are estimates from figures since authors do not provide exact values.

INS, Instituto Nacional de Salud, Colombia; ICP, Instituto Clodomiro Picado, Costa Rica; IB, Instituto Butantan, Brazil; Bioclon, Laboratorios Biolclon, Mexico; INPBA, Instituto Nacional de Producción de Biológicos, Argentina. Values in bold indicate heterologous venoms for the given antivenom. See Material and Methods for additional details.