Table 1. Drug-specific division gains and death gains.
Drug | Division gain ρi | Death gain ρiD |
---|---|---|
DMSO | 1.34 [1.27, 1.36] | 0.0057 [0.0045, 0.0063] |
Trametinib | 1.07 [1.06, 1.08] | 0.019 [0.017, 0.021] |
BEZ235 | 1.09 [1.08, 1.10] | 0.0083 [0.0067, 0.0091] |
Trametinib+BEZ235 | 1.00 [1.00, 1.00] | 0.068 [0.066, 0.071] |
The value of the division gains ρi and the value of the death gains ρiD from each drug-specific AM-optimized dynamics matrix are provided (units: ), where i ∈ {1,2,3,4} is a differentiation-state index, ρ1 = ρ2 = ρ3 = ρ4, and ρ1D = ρ2D = ρ3D = ρ4D. 95% confidence intervals from each drug-specific model ensemble are also shown. Higher values indicate more frequent division or death on average over time compared to lower values.