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. 2019 Mar 11;15(3):e1006840. doi: 10.1371/journal.pcbi.1006840

Table 1. Drug-specific division gains and death gains.

Drug Division gain ρi Death gain ρiD
DMSO 1.34 [1.27, 1.36] 0.0057 [0.0045, 0.0063]
Trametinib 1.07 [1.06, 1.08] 0.019 [0.017, 0.021]
BEZ235 1.09 [1.08, 1.10] 0.0083 [0.0067, 0.0091]
Trametinib+BEZ235 1.00 [1.00, 1.00] 0.068 [0.066, 0.071]

The value of the division gains ρi and the value of the death gains ρiD from each drug-specific AM-optimized dynamics matrix are provided (units: #cellsat(k+1)multiplesof12hours#cellsatkmultiplesof12hours), where i ∈ {1,2,3,4} is a differentiation-state index, ρ1 = ρ2 = ρ3 = ρ4, and ρ1D = ρ2D = ρ3D = ρ4D. 95% confidence intervals from each drug-specific model ensemble are also shown. Higher values indicate more frequent division or death on average over time compared to lower values.