Table 3.
Estimated costs and numbers of repeat revascularization procedures and amputations.
| Average Cost Difference | Target-Vessel Revascularizationc | Surgical Revascularization | Major Amputation | Minor Amputation | |
|---|---|---|---|---|---|
| Stent - No stent | $1425a | $5391f | $32,793g | $71,980h | $34,278h |
| Mean estimate (95% CI) | Mean estimate (95% CI) | Mean estimate (95% CI) | Mean estimate (95% CI) | ||
| Stent - No stent | Estimated number of events difference per procedureb | 0.015498 (−0.034988 to 0.11189) | 0.0002 (−0.0011 to 0.0159) | −0.0003 (−0.00347 to 0.0011) | 0.02 (−0.004 to 0.11384) |
| Benefits (costs, $)d | −$89.5 (−603.2 to 188.6) | −$6.6 (−521.4 to 36.1) | $21.6 (−72.0 to 249.8) | −$648.5 (−3902.2 to 137.1) | |
| Total costs (benefits, $)e | −$542.5 (−5098.8 to 611.6) | ||||
The average procedure cost was calculated as procedure cost divided by number of lesions treated within the procedure.
A logistic model calculated estimated reduction in numbers of repeat endovascular or surgical revascularization and amputation per procedure. Model: Y (clinical event = yes) = b0 + b1*group (stent vs no stent group) + b2*age + b3*gender + b4*diabetes + b5*current smoking status + b6*hypertension + b7*hypercholesterolemia + b8*lesion length + error, where b values are estimates. P(Y) group = stent) = exp (b0 + b1* group = stent) / 1 − exp (b0 + b1*group = stent) and P(Y|group = no stent) = b0 / 1 − exp (b0). Difference in P(Y) = P(Y) group = stent) − P(Y) group = nostent). Difference in estimated based on numbers of events per procedure between stent and non-stent groups that was calculated as a group difference in estimated numbers of repeated intervention, surgical revascularization, and major and minor amputation, respectively.
Target-vessel revascularization (TVR) cost was calculated using the average procedure cost per lesion treated.
Benefits of stent use compared to no use were calculated as difference in estimated numbers of needed intervention • average cost of procedure cost per lesion treated.
Total benefits were calculated as a sum of TVR, surgical revascularization, and major and minor amputation costs.
Average cost of procedure cost per lesion treated.
Cost figure is from a published article,6 and converted to 2015 constant dollars using Consumer Price Index (CPI).
Cost figure is an average cost of below-the-knee and above-the-knee amputation costs from the publication,22 and cost was converted to 2015 constant dollars using CPI.