Invasive Duct Carcinoma, Grade II, Showing Normal CEP 17 and Normal TOP2A Gene Copy Number (A), Histologic section of the tumor, Hx and E stained (X100); (B), Immunostained slide showing high KI-67 LI about 70%(X100). (C), Representative FISH image, showing normal chromosome 17 CEP number (as demonstrated by 1-2 aqua signals per nucleus) and normal TOP 2A gene copy number (as demonstrated by 1-2 red signals per nucleus). Gene to chromosome ratio is 1.