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Invasive Duct Carcinoma, Grade III, with CEP 17 Polysomy and TOP2A Gene Deletion (A), Histologic section of the tumor (X 40); (B), Immunostained slide for KI-67 LI showing proliferation rate 80% (X 40); (C), Representative FISH image showing CEP 17 polysomy (as demonstrated by 4-5 aqua signals) and TOP2A gene deletion (as demonstrated by 2-3 red signals). Gene to chromosome ratio is <0.8.
