Table 3.

Relation of TOP2A Gene Status and CEP 17 with Clinicopathologic Parameters

Clinicopathological variable/ Category	TOP2A amplified (n=5)	TOP2A deleted (n=4)	TOP2A normal (n=41)	P value	CEP17 Normal diploid n=43	CEP17 Polysomy n=7	P value
Age (years)
≤50	2 (6.7%)	2 (6.7%)	26 (86.7%)		28 (93.3%)	2 (6.7%)	0.1
>50	3 (15%)	2 (10%)	15 (75%)	0.47	15 (75%)	5 (25%)
Menopausal status
Post	3 (10%)	4 (13.3%)	23 (76.7%)		23 (76.7%)	7 (23.3%)	0.033
Pre	2 (10%)	0 (0%)	18 (90%)	0.292	20 (100%)	0 (0%)
Family history
Negative	5 (11.4%)	4 (9.1%)	35 (79.5%)	1	37 (84.1%)	7 (15.9%)	0.292
Positive	0 (0%)	0 (0%)	6 (100%)		6 (100%)	0 (0%)
Tumor size
≤5cm	4 (9.1%)	4 (9.1%)	36 (81.8%)	0.717	37 (84.1%)	7 (15.9%)	0.292
>5cm	1 (16.7%)	0 (0%)	5 (83.3%)		6 (100%)	0 (0%)
Lymph node positivity
Yes	3 (9.4%)	3 (9.4%)	26 (81.3%)	1	16 (88.9%)	2 (11.1%)	1
No	2 (11.1%)	1 (5.6%)	15 (83.3%)		27 (84.4%)	5 (15.6%)
Disease stage
I&II	4 (12.1%)	2 (6.1%)	27 (81.8%)	*	28 (84.8%)	5 (15.2%)	0.744
III	1 (5.9%)	2 (11.8%)	14 (82.4%)		15 (88.2%)	2 (11.8%)
Tumor grade
G I&GII	3 (9.1%)	3 (9.1%)	27 (81.8%)	1	27 (81.8%)	6 (18.2%)	0.398
G III	2 (11.8%)	1 (5.9%)	14 (82.4%)		16 (94.1%)	1 (5.9%)
Ki-67 LI
≤20%	0 (0%)	0 (0%)	6 (100%)	0.511	6 (100%)	0 (0%)	1
>20%	5 (11.4%)	4 (9.1%)	35 (79.5%)		37 (84.1%)	7 (15.9%)
Disease outcome
Good	4 (10.3%)	4 (10.3%)	31 (79.5%)	0.812	32 (82.1%)	7 (17.9%)	0.13
Poor	1 (9.1%)	0 (0%)	10 (90.9%)		11 (100%)	0 (0%)

^*P value cannot be calculated due to small number within stratum.