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. 2019 Feb 25;8:e42786. doi: 10.7554/eLife.42786

Figure 6. Post-learning activation of DAN-aSP13 neurons mediates LTM consolidation.

Figure 6.

(A) The MBγ and DAN-aSP13s are repetitively activated during 6 hr training by the olfactory and behavioral cues presented by a mated female, respectively. (B) Males display an enhanced amount of sleep after training for LTM. Enhanced sleep is mediated by the vFB neurons in response to a learning induced sleep drive while the remaining amount of sleep is regulated by dFB neurons in response to homeostatic sleep drive. Only vFB neurons activate DAN-aSP13s. Dopamine released as a result of DAN-aSP13s activation stimulates molecular processes in the γKCs neurons that involve synthesis of new proteins essential for LTM memory persistence. (C) Subsequently, experienced males suppress their courtship towards mated females for 24 hr or longer.