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. 2019 Mar 21;8:e41814. doi: 10.7554/eLife.41814

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© 2019, Dai et al

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Figure 7. — Representative intracardiac atrial electrogram recordings and corresponding surface ECG are shown from (A) R26^CreERT2, (B)Tbx5^fl/fl;R26^CreERT2, (C)Pln^-/-;R26^CreERT2, (D)Tbx5^fl/fl;Pln^-/+;R26^CreERT2, (E)Tbx5^fl/fl;Pln^-/-;R26^CreERT2 atrial cardiomyocytes. A, atrial electrical signal; V, far field ventricular electrical signal. (F) AF was reproducibly demonstrated in 6/6 Tbx5 knockouts in contrast to 1/11 Pln/Tbx5 double knockouts, indicating rescue of atrial arrhythmogenesis. P values were determined by Fisher’s exact test (n = 5 R26^CreERT2, n = 6 Tbx5^fl/fl;R26^CreERT2, n = 7 Pln^-/-;R26^CreERT2, and n = 5 Tbx5^fl/fl;Pln^-/+;R26^CreERT2, n = 11 Tbx5^fl/fl;Pln^-/- mice).