TABLE 2.

Therapy courses

	Drug	Dose	Day
Prephase	Prednisone	30 mg/m2	1 to 5	Orally in 3 divided doses
	Cyclophosphamide	200 mg/m2	1 to 5	1-hour IV infusion
Intrathecal	Methotrexate	Age-adjusted	1 or 1 and 4¥
	Hydrocortisone
	Cytarabine
Course A/AA	Dexamethasone	10 mg/m2	1 to 5	Orally in 3 divided doses
	Ifosfamide/MESNA	400 mg/m2	1 to 5	1-hour IV infusion
	Methotrexate	1–3 g/m2	1	10% infused as a push and 90% in 3 hours
	Leucovorin	15 mg/m2 (*)	2	First dose starting at 24 hours after the start of the infusion of methotrexate and continued every 6 hours for 12 doses.
	Cytarabine	150 mg/m2	4 and 5	30-minute IV infusion every 12 hours (4 doses).
	Etoposide	100 mg/m2	4 and 5	1-hour IV infusion daily (2 doses)
	Vincristine(*)	1.5 mg/m2	1	IV push
Intrathecal	Methotrexate	Age-adjusted	1 or 4 doses weekly ¥
	Hydrocortisone
	Cytarabine
Course B/BB Intrathecal	Dexamethasone Cyclophosphamide Methotrexate Leucovorin Doxorubicin Vincristine (**) Methotrexate Hydrocortisone Cytarabine	10 mg/m2 200 mg/m2 1–3 g/m2 15 mg/m2 (*) 25 mg/m2 1.5 mg/m2 Age-adjusted	1 to 5 1 to 5 1 2 4 and 5 1 1	Divided into 3 doses, given orally 1-hour IV infusion 10% infused as a push and 90% in 3 hours First dose starting at 24 hours after the start of the infusion of methotrexate and continued every 6 hours for 12 doses. 1-hour IV infusion IV push

^*Block AA only

^**Block BB only

^¥Patients with central nervous system involvement