Oncoprint of significantly altered genes in 45 advanced anal cancer cases sequenced with the MSK-IMPACT targeted next generation sequencing assay; tumors analyzed from patients treated with platinum-containing regimens in the first line setting (31 cases) are shown together on the left side of the figure. Abbreviations: PFS mo, progression free survival in months; Mut/Mb, mutations/megabase, HPV, Human papillomavirus; CR, complete response; PR, partial response; SD, stable disease; NE, not evaluated; PD, progressive disease