Table 3.

Toxicity possibly, probably, or definitely realted to FOLFCIS

Toxicity	Grade 2	Grade 3	Grade 4
	No. (%)	No. (%)	No. (%)
Hematologic
Anemia	18 (34)	10 (19)	0
Thrombocytopenia	5 (9)	0	1 (2)
Neutropenia	12 (23)	13 (25)	5 (9)
Febrile neutropenia	NA	1 (2)	0
Non-hematologic
Hypersensitivity	4 (8)	0	0
Nausea	11 (21)	1 (2)	0
Vomiting	4 (8)	0	0
Dehydration	5 (9)	4 (8)	0
Fatigue	24 (45)	5 (9)	0
Diarrhea	4 (8)	3 (6)	0
Mucositis	7 (13)	0	0
Neuropathy	3 (6)	0	0
Acute kidney injury	1 (2)	1 (2)	0
Hypokalemia	1 (2)	1 (2)	0
Hemorrhage	5 (9)	0	0
AST or ALT	3 (6)	0	0
elevation

Abbreviation: ALT, alanine aminotransferase; AST, aspartate aminotransferase; NA, Not applicable.