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. Author manuscript; available in PMC: 2020 May 1.
Published in final edited form as: Eur J Pharm Biopharm. 2018 May 24;138:23–29. doi: 10.1016/j.ejpb.2018.05.030

Figure 1.

Figure 1.

Colon tissue (A) TFV levels and (B) colon tissue TFV-DP levels measured 15 min after enema dosing with a range of TFV enema concentrations (0.085–10 mg/ml). The red dotted lines in both figures represent the median levels measured in a human study 30 min after a single dose of 10 mg/ml (1%) TFV gel (vaginal formulation, VF) [22]. Part (B) also includes TFV-DP levels measured in mouse colon tissue 15 min after administration of the TFV VF gel.