. Author manuscript; available in PMC: 2020 May 1.

Published in final edited form as: Eur J Pharm Biopharm. 2018 May 24;138:23–29. doi: 10.1016/j.ejpb.2018.05.030

Table 2.

Fold changes in plasma TFV AUC_last when comparing various enema formulations. Values in the table represent the fold increase when comparing row > column. N/A represents redundant comparisons that are omitted for clarity.

	TAF	TFV/NaHCO₃	TFV/NaOH	CMX
TDF/NaHCO₃	1.5^*	1.9^*	2.0^*	69^*
TAF	N/A	1.2	1.3	45^*
TFV/NaHCO₃	N/A	N/A	1.1	37^*
TFV/NaOH	N/A	N/A	N/A	34^*

p < 0.05