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. 2019 Feb 5;133(12):1335–1345. doi: 10.1182/blood-2018-10-878082

Figure 4.

Figure 4.

Cxcl1−/−mice have reduced amplification of early granulocyte precursors in pneumococcal lung infection-induced emergency granulopoiesis. (A-F) WT and Cxcl1−/− mice were infected intratracheally with S pneumoniae 6303 (5 × 104 CFU). FACS analysis plot (A), percentage (B), and number (per femur/tibia) (C) of hematopoietic stem cells ((c-Kit+Sca-1+Lin−) at 48 hours postinfection. FACS dot plot (D), percentage (E), and number (per femur/tibia) (F) of myeloid progenitor cells (c-Kit+Sca-1−Lin−) at 48 hours postinfection (n = 5-6 mice/infection group; n = 3 mice/control group). All experiments were performed 3 times. Statistical significance was determined by unpaired Student t (B-C,E-F). *P < .05; **P < .01.