Figure 5.

Heatmap of multivariable analysis of the effect of RTS,S/AS01E vaccination and demographic, clinical, and epidemiological variables on IgG subclass levels to Plasmodium falciparum pre-erythrocytic and blood stage antigens at baseline. Linear regression was performed with antibody levels (log₁₀MFI) as outcome and other covariates adjusted (in parenthesis the reference category). Color coded cells show the 10^∧Beta of each predictor (columns) for each model (rows). Only results with a significant (<0.05) p-value are shown. Antigen colors show the P. falciparum life cycle stage in which they are expressed: Pre-erythrocytic (PE) antigens from sporozoite stage (light purple), PE from liver stage (dark purple), blood stage (BS) antigens from merozoite stage (orange), BS from trophozoite stage (yellow).