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. 2019 Mar 15;10:439. doi: 10.3389/fimmu.2019.00439

Figure 7.

Figure 7

Forest plots of multivariable analysis of the association between IgG subclass responses to Plasmodium falciparum pre-erythrocytic and blood stage antigens, and malaria protection. Logistic regression models with antibody levels at month 3 (M3), or change in M3 and M0 levels (M3-M0), as predictors and clinical malaria as outcome, adjusted by covariates that entered the models according to the minimum akaike information criterion (RTS,S vaccination, age cohort, site, M0 antibody levels, WAZ and prior malaria episodes, depending on the antigen/subclass). OR: Odds ratio with 95% confidence intervals (CI). OR with a CI below (protection) or above (risk) 1 are represented by a colored circle. Associations with a CI below or above 1 (asterisks) in stratified analysis including only RTS,S vaccinees: IgG3 to LSA1 at M3: OR = 0.13 (0.02;0.71), p = 0.03; IgG3 to MSP1 bl2 Mad20 at M3: OR = 0.01 (0;0.33), p = 0.02; IgG3 to MSP1 bl2 RO33 at M3: OR = 0.33 (0.09;0.99), p = 0.056; IgG3 to SSP2 (TRAP) at M3-M0: OR = 0.23 (0.05;0.86), p = 0.04; IgG3 MSP1 bl2 RO33 at M3-M0: 0.47 (0.2;0.99), p = 0.053; IgG4 LSA1 at M3: OR = 0.07 (0;0.65), p = 0.058; IgG4 to CelTOS at M3: OR = 0 (0;0.28), p = 0.03; IgG4 to MSP1 bl2 Mad20 at M3: OR = 0 (0;0.25), p = 0.055.