Table 4.
Summary of the slopes (β) of the linear regressions explaining the MDS-UPDRS components at baseline (BL) and the MDS-UPDRS variation (ΔMDS-UPDRS) 1 year after the baseline.
| Time point | Dependent variable | Model predictors: β slope |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| GM vol in PFC and PMC | MD in OP | MD in PN | FA in PT | DAT in Put | Interaction DAT in Put – MD PN | Interaction DAT in Put – GM vol in PFC and PMC and IN | Age | Gender | Dominant side | ||
| BL | MDS-UPDRS1 | 2.8 | −3.7 | 104.7 | −1.8 | 8.6 × 104 | −3.1 × 103 | −9.4 | 104 | 0.1 | −0.1 |
| MDS-UPDRS2 | −0.54 | −19.8 | 50.2 | −6.5 | 3.4 × 104 | −1.5 × 104 | 9.8 | 1.1 × 104 | −0.1 | −0.7 | |
| MDS-UPDRS3 | 0.8 | −6.7 | 149 | −2.9 | 1.9 × 105 | −1.9 × 104 | 3.7 | 2.6 × 104 | 0.23 | 3.3 | |
| MDS-UPDRS tot | 3 | −30.3 | 303 | −11.2 | 3.1 × 105 | 3.8 × 104 | 4 | 4.8 × 104 | 0.36 | 3.1 | |
| Δ | MDS-UPDRS1 PD on med+no med | −2 | −9.1 | 19.2 | −0.4 | −3.2 × 104 | −8.5 × 103 | 3.5 | 5.1 × 103 | 0.1 | −1.1 |
| MDS-UPDRS1 PD on med | −3.4 | 23.2 | 81.4 | −1.9 | −2.3 × 105 | −2.6 × 104 | −8.3 | −3.1 × 103 | 0.1 | −1.4 | |
| MDS-UPDRS1 PD no med | 1.2 | −14.5 | −63.4 | −1.3 | 5.6 × 103 | −7.2 × 103 | 11.5 | 1.1 × 104 | 0.04 | −1.7 | |
| MDS-UPDRS2 PD on med+no med | 2.3 | −1 | −29.7 | −0.6 | −7.5 × 104 | 6.4 × 103 | 7.6 | 1.7 × 104 | −0.01 | 0.5 | |
| MDS-UPDRS2 PD on med | −9.4 | −20.1 | 235 | 9.3 | 3.3 ×104 | 3.2 ×104 | −24.1 | 1.5 ×104 | 0.07 | 2.9 | |
| MDS-UPDRS2 PD no med | 5.5 | −26.8 | −116.8 | −2.8 | −5.9 ×104 | −865.3 | 9.5 | 2.3 ×104 | −0.03 | −0.5 | |
| MDS-UPDRS3 PD on med+no med | 9.5 | 29.6 | 14.1 | −1.3 | −2.2 × 105 | 1.1 × 104 | 7.2 | 2.1 × 104 | −0.1 | −1 | |
| MDS-UPDRS3 PD on med | −5 | −42.8 | 447.3 | 13.6 | 3.3 × 105 | 1.1 × 105 | −139.7 | 1.2 × 104 | −0.03 | 2.7 | |
| MDS-UPDRS3 PD no med | 9.8 | −31 | −240.1 | −2.9 | −3.1 × 105 | −4.2 × 103 | 15.2 | 2.5 × 104 | 0.02 | −3 | |
| MDS-UPDRS tot PD on med+no med | 9.8 | 19.5 | 3.7 | −2.3 | −3.3 × 105 | 9.1 × 103 | 18.3 | 4.3 × 104 | −0.01 | −1.6 | |
| MDS-UPDRS tot PD on med | −17.7 | −40 | 763.8 | 21.1 | 1.3 × 105 | 1.1 × 105 | −172.1 | 2.4 × 104 | 0.1 | 4.1 | |
| MDS-UPDRS tot PD no med | 16.5 | −72.3 | −420.3 | −7.1 | −3.6 × 105 | −1.2 × 104 | 36.1 | 5.9 × 104 | 0.03 | −5.3 | |
Models for the ΔMDS-UPDRS were estimated separately for the patients without medication 1 year after baseline (no med), for the patients on L-Dopa 1 year after baseline (on med) and for the patients of both groups together (on med + no med). The model predictors were the mean imaging values extracted from the following regions: IN, insula; OP, operculum; PFC, prefrontal cortex; PMC, premotor cortex; PN, pons nuclei; Put, putamen; PT, pontine tegmentum. Bold characters indicate a significant (p < 0.05) model – (p < 0.01) regressors.