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. 2019 Mar 15;7:71. doi: 10.3389/fped.2019.00071

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Copyright © 2019 Kim, Montes-Mojarro, Fend and Quintanilla-Martinez.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Extranodal, NK/T-cell lymphoma, nasal type in the skin. (A) Panoramic view of a skin biopsy shows a partially circumscribed nodule located in the subcutaneous tissue (H&E, scanned slide); (B) The tumor cells are CD56 positive (immunohistochemistry, scanned slide). (C) The lymphoid cells are positive for EBV-encoded small RNA in situ hybridization (EBER) (in situ hybridization) (D) The infiltrate is composed of large atypical cells with irregular nuclei. The tumor cells surround the adipocytes revealing a “lace-like pattern” mimicking panniculitis-like T-cell lymphoma. Numerous apoptotic bodies are observed (H&E, 400×); (E,F) Higher magnification demonstrates that the neoplastic cells are positive for CD56 and EBER, (immunohistochemistry and in situ hybridization 400×).