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. 2019 Mar 15;10:468. doi: 10.3389/fimmu.2019.00468

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Copyright © 2019 Frumento, Zuo, Verma, Croft, Ramagiri, Chen and Moss.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CD117⁺ is selectively expressed on CD8⁺ T cells and incremental expression is observed after serial episodes of activation. (A) The kinetics of activation-induced CD117 expression was determined on CBMC or CD8⁺ T cells purified from UCB by immunomagnetic separation. Gating was set on CD3⁺/CD8⁺ cells. Data are from three independent UCB units. (B) The level of CD117 expression was determined on CD8⁺ following either a single episode of stimulation at day 0 (gray arrow and diamonds) or after re-stimulation at day 12 and 20 (white arrows and squares). Data are from three independent CBMC samples. (C) CD117⁺ and CD117⁻ cells were enriched from purified CD8⁺ T cells from UCB 12 days after activation and re-stimulated with anti-CD3 plus IL-2. The level of CD117 expression is shown before and 4 days after re-activation. Data are from three independent samples.