TABLE 4.

Genomic changes in mating products after passage in fluconazole

Mating product/progeny	Fluconazole MIC (µg/ml)	Genomic change(s) in mating product progenya
EM1	8
EM1P3A-1	64	Loss of wild-type MRR1, wild-type ERG11, and MTLα
EM1P8A-1	128	Loss of wild-type MRR1, wild-type ERG11, and MTLα
EM1P8A-3	128	Loss of wild-type MRR1, wild-type ERG11, and MTLα
ME1	4
ME1P4A-2	32	Loss of wild-type MRR1
ME1P4A-3	32	Loss of wild-type MRR1
ME1P5A-2	64	Loss of wild-type MRR1
ET1	8
ET1P2A-2	16
ET1P7A-3	32	Loss of wild-type TAC1-1, decrease in ERG11* and MTLa
TE1	4
TE1P6A-1	16	Decrease in wild-type TAC1, ERG11*, and MTLα
TE1P6A-2	16	Loss of wild-type TAC1, ERG11*, and MTLα
TE1P12A-1	128	Loss of wild-type TAC1, increase in ERG11* and MTLα
EU1	4
EU1P6A-3	32	Decrease in wild-type ERG11 and MTLα
EU1P8A-3	64	Loss of wild-type ERG11 and MTLα, increase in UPC2*
UE1	2
UE1P2A-1	4	Increase in UPC2*
UE1P4A-3	16	Increase in UPC2*, ERG11*, and MTLα
MT1	8
MT1P3A-3	16	Decrease in wild-type MRR1
MT1P5A-2	32	Loss of wild-type MRR1
MT1P5A-3	32	Loss of wild-type MRR1, wild-type TAC1, and MTLa
TM1	4
TM1P6A-2	16	Loss of wild-type TAC1 and MTLα
TM1P6A-3	16	Loss of wild-type TAC1 and MTLα
TM1P10A-1	64	Loss of wild-type MRR1, wild-type TAC1, and MTLα
MU1	4
MU1P5A-1	32	Decrease in wild-type MRR1
MU1P7A-1	64	Loss of wild-type MRR1
UM1	4
UM1P3A-3	32	Loss of wild-type MRR1, increase in UPC2*
UM1P3A-1	64	Loss of wild-type MRR1
TU1	4
TU1P6A-3	16
TU1P11A-1	64	Loss of wild-type TAC1 and MTLα, increase in UPC2*
TU1P11A-3	64	Loss of wild-type TAC1 and MTLα, increase in UPC2*
UT1	8
UT1P2A-2	16	Decrease in wild-type TAC1 and MTLa, increase in UPC2*
UT1P2A-3	16	Decrease in wild-type TAC1 and MTLa, increase in UPC2*
UT1P5A-1	32	Loss of wild-type TAC1 and MTLa
UT1P5A-2	32	Decrease in wild-type TAC1 and MTLa, increase in UPC2*

^aDecreases and increases in copy number are relative to the other allele.