Table 1.
Cardiac structure and function by echocardiography and in vivo hemodynamics.
| Echocardiography (n) | ClockΔ19/Δ19 HF mice | WT HF mice | ClockΔ19/Δ19 Controls | WT Controls |
|---|---|---|---|---|
| 8 | 8 | 5 | 5 | |
| Baseline | ||||
| LVIDd (mm) | 3.95 ± 0.03 | 3.95 ± 0.02 | 3.97 ± 0.03 | 3.95 ± 0.02 |
| LVIDs (mm) | 2.32 ± 0.02 | 2.35 ± 0.02 | 2.38 ± 0.03 | 2.33 ± 0.01 |
| EF (%) | 78.39 ± 0.40 | 77.42 ± 0.48 | 76.98 ± 0.57 | 78.10 ± 0.37 |
| FS (%) | 41.28 ± 0.39 | 40.37 ± 0.43 | 40.02 ± 0.51 | 41.01 ± 0.34 |
| 1 week post-infarction | ||||
| LVIDd (mm) | 4.94 ± 0.08* | 5.11 ± 0.16§ | 4.03 ± 0.02 | 3.98 ± 0.03 |
| LVIDs (mm) | 3.69 ± 0.09* | 3.87 ± 0.15§ | 2.43 ± 0.03 | 2.38 ± 0.05 |
| EF (%) | 56.55 ± 1.58* | 54.76 ± 1.97§ | 76.50 ± 0.51 | 77.26 ± 1.02 |
| FS (%) | 25.40 ± 0.94* | 24.50 ± 1.15§ | 39.61 ± 0.45 | 40.25 ± 0.90 |
| 8 week - HF | ||||
| LVIDd (mm) | 5.09 ± 0.08*† | 5.65 ± 0.11§ | 4.05 ± 0.03 | 4.00 ± 0.03 |
| LVIDs (mm) | 3.81 ± 0.09*† | 4.45 ± 0.11§ | 2.46 ± 0.03 | 2.39 ± 0.03 |
| EF (%) | 56.37 ± 1.17*† | 49.42 ± 1.08§ | 76.08 ± 0.32 | 77.11 ± 0.48 |
| FS (%) | 25.38 ± 0.68*† | 21.52 ± 0.57§ | 39.23 ± 0.24 | 40.11 ± 0.48 |
| Hemodynamics (HF) | ||||
| LVESP (mmHg) | 88.2 ± 1.5* | 87.0 ± 0.8§ | 97.9 ± 1.4 | 98.4 ± 0.8 |
| LVEDP (mmHg) | 3.5 ± 1.5* | 2.5 ± 1.1 | −0.4 ± 0.4 | 0.4 ± 0.7 |
| LVESV (μl) | 23.5 ± 1.0*† | 36.4 ± 1.4§ | 9.8 ± 0.9 | 10.6 ± 0.4 |
| LVEDV (μl) | 46.4 ± 0.6*† | 54.7 ± 1.3§ | 34.7 ± 1.4 | 35.9 ± 1.1 |
| SV (μl) | 22.9 ± 0.6† | 18.3 ± 0.5§ | 24.0 ± 0.6 | 24.1 ± 1.0 |
| CO (mL/min) | 11.5 ± 0.4† | 9.6 ± 0.5§ | 12.7 ± 0.6 | 13.3 ± 0.8 |
| dP/dtmax (mmHg/sec) | 6939 ± 394* | 5959 ± 258§ | 10420 ± 674 | 9744 ± 864 |
| dP/dtmin (mmHg/sec) | 5905 ± 458* | 5278 ± 258§ | 9403 ± 1030 | 9830 ± 966 |
| SBP (mmHg) | 82.9 ± 1.0*† | 89.3 ± 0.9§ | 97.8 ± 1.2 | 98.1 ± 1.0 |
| DBP (mmHg) | 58.7 ± 0.7* | 60.6 ± 0.5 | 64.3 ± 1.4 | 63.6 ± 0.6 |
| MAP (mmHg) | 66.3 ± 0.7*† | 69.7 ± 0.3§ | 74.7 ± 0.9 | 74.3 ± 0.3 |
| Morphometry (HF) | ||||
| HW (mg) | 158 ± 2* | 162 ± 6§ | 140 ± 3 | 130 ± 3 |
| HW:BW (mg/g) | 5.03 ± 0.10*† | 5.86 ± 0.25§ | 4.43 ± 0.15 | 4.14 ± 0.12 |
| HW:TL (mg/mm) | 7.79 ± 0.09* | 8.10 ± 0.27§ | 6.90 ± 0.15 | 6.46 ± 0.13 |
LV, left ventricle; LVIDd/s, internal dimension diastole/systole, %EF, %ejection fraction; %FS, % fractional shortening; LVESP/DP, end systolic/diastolic pressure; LVESV/DV, end systolic/diastolic volume; SV, stroke volume; CO, cardiac output; dP/dtmax dP/dtmin, derivatives of LV pressure; SBP/DBP/MAP, systolic, diastolic, mean arterial pressure; HW, heart weight; BW, body weight; TL, tibia length; *P < 0.05 ClockΔ19/Δ19-HF vs ClockΔ19/Δ19-control, §P < 0.05 WT-HF vs. WT-control, †P < 0.05 ClockΔ19/Δ19-HF vs. WT-HF by two way ANOVA followed by Tukey post hoc. Values are mean±SEM.