Table 2.
Key genes underlying dichotomous neurobiological responses in Clock∆19/∆19 mice.
| Gene | Gene Name |
|---|---|
| Bmal1 | Brain And Muscle ARNT-Like 1 |
| Per2 | Period 2 |
| Cry2 | Cryptochrome 2 |
| Dbp | D Site Of Albumin Promoter (Albumin D-Box) Binding Protein |
| Tef | Thyrotrophic Embryonic Factor |
| Gabra2 | Gamma-Aminobutyric Acid Type A Receptor Alpha2 Subunit |
| Fabp7 | Fatty Acid Binding Protein 7 |
| Adcy5 | Adenylate Cyclase 5 |
| Ppp1r1b | Protein Phosphatase 1 Regulatory Inhibitor Subunit 1B |
| Gng7 | G Protein Subunit Gamma 7 |
| Drd2 | Dopamine Receptor D2 |
| Npy | Neuropeptide Y |
| Pde1b | Phosphodiesterase 1B |
| Hdac1 | Histone Deacetylase 1 |
| Adora2a | Adenosine A2a Receptor |
| Grm2 | Glutamate Metabotropic Receptor 2 |
| Slc38a3 | Solute Carrier Family 38 Member 3 |
| Camk2n2 | Calcium/Calmodulin Dependent Protein Kinase II Inhibitor 2 |
| Phactr2 | Phosphatase And Actin Regulator 2 |
| Mid1 | Midline 1 |
| Ndn | Necdin |
| Neurl1b | Neuralized E3 Ubiquitin Protein Ligase 1B |
| Nlgn3 | Neuroligin 3 |
| Mag | Myelin Associated Glycoprotein |
| Mfn2 | Mitofusin 2 |
| Grm3 | Glutamate Metabotropic Receptor 3 |
| Ndn | Necdin |
| Irak1 | Interleukin 1 Receptor Associated Kinase 1 |
| Rapgef4 | Rap Guanine Nucleotide Exchange Factor 4 |
| Cspg5 | Chondroitin Sulfate Proteoglycan 5 |
Genes listed are as profiled in Fig. 6, and were identified as significantly different in the mPFC, or hippocampus, or both. Further details about these genes are provided in Supplementary Table S1, including Affymetrix identifiers, fold change values, gene expression values under all conditions tested (baseline, MI, HF) in Clock∆19/∆19 and WT mice, chromosome location, and tags to esemble, entrezgene, genebank and GO databases. Additional genes identified but not mapped in Fig. 6 are also provided in Supplementary Table S1.