Table 1.
Demographic and clinical characteristics of the participants. Notes: ADD = Alzheimer’s disease dementia; OND = other neurological disorders; CU = cognitively unimpaired; MMSE = Mini-Mental State Examination; CDR = Clinical Dementia Rating scale; CDR-SB = CDR-Sum of Boxes; APOE = apolipoprotein E; Aβ, amyloid beta. Values are mean (standard deviation) or numbers (%).
| Variables | ADD (n = 35) | OND (n = 18) | CU (n = 26) | P value | P < 0.05§ |
|---|---|---|---|---|---|
| Age, years | 75.8 (9.9) | 76.9 (7.5) | 68.9 (5.7) | 0.002* | b, c |
| Female | 26 (74.3%) | 12 (66.7%) | 22 (84.6%) | 0.373† | |
| Education, years | 7.4 (5.0) | 7.0 (4.6) | 6.7 (4.8) | 0.861* | |
| MMSE | 15.2 (3.7) | 18.9 (5.5) | 26.1 (2.8) | <0.001‡ | a, b, c |
| CDR 0: 0.5: 1: 2: 3 | 0: 12: 15: 7: 1 | 0: 12: 4: 2: 0 | 26: 0: 0: 0: 0 | <0.001† | |
| CDR-SB | 6.34 (4.05) | 3.94 (3.67) | 0.19 (0.29) | <0.001‡ | a, b, c |
| APOE ε4 carrier | 12/33 (36.4%) | 1/13 (7.7%) | 3/22 (13.6%) | 0.041† | |
| Aβ deposition on PET | 28/28 | 0/15 | 0/20 | <0.001† |
*P value from analysis of variance; †Results from chi-square tests; ‡P value from analysis of covariance with age as a covariate; §Pairwise comparisons on age between diagnosis groups were conducted with Tukey method, and pairwise comparisons on MMSE and CDR-SB between diagnosis groups were conducted with Bonferroni post hoc analysis; a, ADD vs. OND; b, ADD vs. CU; c, OND vs. CU.