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. 2019 Mar 21;9:4971. doi: 10.1038/s41598-019-41369-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The steps of Hierarchical3DGenome algorithm to reconstruct high-resolution models of chromosomes. The seven steps that Hierarchical3DGenome takes to reconstruct high-resolution models of chromosomes are: (1) break a chromosome into chromosomal domains according to input data and represent each domain as a point or bead, (2) build a 3D model of the entire chromosome at low resolution, (3) create a contact matrix for each domain, such that for n domains there are n contact matrices, (4) build 3D model of high resolution for each domain, (5) scale the 3D Models of the entire chromosome at low resolution to match with the models of the domains at high resolution, (6) substitute beads in low-resolution models with their high-resolution domain models, and (7) refine the high-resoluiton models of the entire chromosome to satisfy inter-domain contacts.