Table 1.
Examples of mitochondrial-targeted enzymes regulated by PGC-1/ERR
| Metabolic process | Major enzymes | Drug | References |
|---|---|---|---|
| Glycolysis | Hexokinase 2 (HK2) | 2-DG, XCT790 | 140– 142 |
| Lactate dehydrogenases (LDHA, LDHB) | AT-101, FX11, Cpd29 | 29, 143 | |
| Pyruvate kinase (PKM2) | TLN-232/CAP-232 | 144, 145 | |
| TCA cycle | Succinate dehydrogenase (SDHB) | 3-BrPA, XCT790 | 25, 146, 147 |
| Isocitrate dehydrogenases−1 and −2 (IDH1, IDH2, IDH3A) | Enasidenib, ivosidenib, Cpd29 | 17, 25, 148 | |
| Fumarate hydratase (FH) | Cpd29 | 17, 25 | |
| OxPhos | Mitochondrial complex I | Metformin, phenformin, Cpd29 | 11, 17, 149, 150 |
| Amino acid metabolism | Glutamic-oxaloacetic transaminase−1 and −2 (GOT1, GOT2) | Aminooxyacetate | 25, 151 |
| Lipid metabolism | Carnitine palmitoyltransferase 1 (CPT1) | Etomoxir | 140, 152 |
| Fatty acid synthase (FASN) | Orlistat, cerulenin, TVB-2640 | 14, 110 |