Table 2.
Predictive accuracy in the training and validation sets
| Training set | Validation set | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sensitivity (95% CI) | Specificity (95% CI) | PPV (95% CI) | NPV (95% CI) | Accuracy (95% CI) | AUC (95% CI) | Sensitivity (95% CI) | Specificity (95% CI) | PPV (95% CI) | NPV (95% CI) | Accuracy (95% CI) | AUC (95% CI) | |
| miR-4736 | 0.88 (0.82–0.94) | 0.88 (0.84–0.92) | 0.77 (0.70–0.85) | 0.94 (0.91–0.97) | 0.88 (0.85–0.92) | 0.95 (0.92–0.97) | 0.81 (0.74–0.89) | 0.83 (0.78–0.88) | 0.67 (0.59–0.76) | 0.91 (0.87–0.95) | 0.83 (0.79–0.87) | 0.92 (0.89–0.95) |
| miR-6836-3p | 0.90 (0.84–0.95) | 0.78 (0.73–0.83) | 0.65 (0.57–0.72) | 0.94 (0.91–0.97) | 0.82 (0.78–0.86) | 0.91 (0.89–0.94) | 0.93 (0.87–0.98) | 0.71 (0.65–0.76) | 0.58 (0.50–0.65) | 0.96 (0.93–0.99) | 0.77 (0.73–0.82) | 0.90 (0.87–0.94) |
| miR-4258 | 0.91 (0.86–0.97) | 0.78 (0.73–0.83) | 0.66 (0.58–0.73) | 0.95 (0.92–0.98) | 0.82 (0.79–0.86) | 0.90 (0.87–0.93) | 0.93 (0.89–0.98) | 0.71 (0.65–0.77) | 0.58 (0.51–0.66) | 0.96 (0.93–0.99) | 0.78 (0.73–0.82) | 0.86 (0.83–0.90) |
| miR-4787-3p | 0.91 (0.86–0.97) | 0.78 (0.73–0.83) | 0.66 (0.58–0.73) | 0.95 (0.92–0.98) | 0.82 (0.79–0.86) | 0.91 (0.88–0.94) | 0.87 (0.80–0.93) | 0.69 (0.63–0.75) | 0.55 (0.47–0.62) | 0.92 (0.89–0.96) | 0.74 (0.70–0.79) | 0.87 (0.83–0.91) |
| miR-6789-5p | 0.90 (0.84–0.95) | 0.75 (0.69–0.80) | 0.61 (0.54–0.69) | 0.94 (0.91–0.97) | 0.79 (0.75–0.83) | 0.88 (0.85–0.92) | 0.93 (0.87–0.98) | 0.71 (0.65–0.76) | 0.58 (0.50–0.65) | 0.96 (0.93–0.99) | 0.77 (0.73–0.82) | 0.89 (0.86–0.93) |
| miR-658 | 0.97 (0.93–1.00) | 0.66 (0.60–0.72) | 0.56 (0.49–0.63) | 0.98 (0.95–1.00) | 0.76 (0.71–0.80) | 0.88 (0.85–0.91) | 0.93 (0.89–0.98) | 0.59 (0.53–0.66) | 0.50 (0.43–0.57) | 0.95 (0.92–0.99) | 0.70 (0.65–0.74) | 0.86 (0.82–0.90) |
| miR-8059 | 0.92 (0.87–0.97) | 0.67 (0.61–0.73) | 0.56 (0.49–0.63) | 0.95 (0.92–0.98) | 0.75 (0.70–0.79) | 0.84 (0.80–0.88) | 0.91 (0.85–0.96) | 0.57 (0.51–0.63) | 0.48 (0.41–0.54) | 0.93 (0.89–0.97) | 0.67 (0.62–0.72) | 0.80 (0.75–0.84) |
| miR-4665-3p | 0.86 (0.80–0.93) | 0.75 (0.70–0.80) | 0.61 (0.53–0.68) | 0.92 (0.89–0.96) | 0.78 (0.74–0.83) | 0.85 (0.81–0.89) | 0.88 (0.82–0.94) | 0.66 (0.60–0.72) | 0.53 (0.45–0.60) | 0.93 (0.89–0.97) | 0.73 (0.68–0.77) | 0.83 (0.79–0.88) |
| miR-663b | 0.73 (0.64–0.81) | 0.75 (0.70–0.80) | 0.57 (0.49–0.65) | 0.86 (0.81–0.90) | 0.74 (0.70–0.79) | 0.79 (0.74–0.84) | 0.75 (0.66–0.83) | 0.71 (0.66–0.77) | 0.53 (0.45–0.61) | 0.87 (0.82–0.91) | 0.72 (0.68–0.77) | 0.80 (0.75–0.85) |
| miR-4649-5p | 0.90 (0.84–0.95) | 0.60 (0.54–0.66) | 0.50 (0.44–0.57) | 0.93 (0.89–0.97) | 0.69 (0.65–0.74) | 0.78 (0.74–0.83) | 0.97 (0.94–1.00) | 0.55 (0.49–0.61) | 0.48 (0.41–0.55) | 0.98 (0.95–1.00) | 0.68 (0.63–0.73) | 0.78 (0.74–0.83) |
| miR-4281 | 0.60 (0.51–0.69) | 0.76 (0.71–0.81) | 0.53 (0.44–0.62) | 0.81 (0.76–0.86) | 0.71 (0.66–0.76) | 0.71 (0.66–0.77) | 0.58 (0.48–0.67) | 0.69 (0.64–0.75) | 0.45 (0.37–0.53) | 0.79 (0.74–0.85) | 0.66 (0.61–0.71) | 0.71 (0.65–0.77) |
| miR-762 | 0.68 (0.60–0.77) | 0.74 (0.69–0.79) | 0.54 (0.46–0.63) | 0.84 (0.79–0.89) | 0.72 (0.68–0.77) | 0.76 (0.71–0.81) | 0.73 (0.64–0.81) | 0.71 (0.66–0.77) | 0.52 (0.44–0.60) | 0.86 (0.81–0.91) | 0.72 (0.67–0.77) | 0.79 (0.74–0.85) |
| Index Ia | 0.91 (0.86–0.97) | 0.90 (0.87–0.94) | 0.81 (0.74–0.88) | 0.96 (0.93–0.98) | 0.91 (0.88–0.94) | 0.97 (0.95–0.98) | 0.84 (0.77–0.91) | 0.88 (0.84–0.92) | 0.76 (0.68–0.83) | 0.93 (0.90–0.96) | 0.87 (0.84–0.91) | 0.95 (0.93–0.97) |
| Index IIb | 0.91 (0.86–0.97) | 0.90 (0.86–0.93) | 0.80 (0.73–0.87) | 0.96 (0.93–0.98) | 0.90 (0.87–0.93) | 0.96 (0.95–0.98) | 0.86 (0.79–0.93) | 0.88 (0.83–0.92) | 0.75 (0.67–0.83) | 0.94 (0.90–0.97) | 0.87 (0.84–0.91) | 0.95 (0.93–0.97) |
| Index IIIc | 0.97 (0.95–1.00) | 0.88 (0.84–0.92) | 0.79 (0.72–0.86) | 0.99 (0.97–1.00) | 0.91 (0.88–0.94) | 0.98 (0.97–0.99) | 0.92 (0.86–0.97) | 0.87 (0.83–0.91) | 0.75 (0.68–0.83) | 0.96 (0.93–0.99) | 0.88 (0.85–0.92) | 0.97 (0.95–0.98) |
| Index IVd | 0.98 (0.96–1.00) | 0.91 (0.88–0.95) | 0.83 (0.77–0.90) | 0.99 (0.98–1.00) | 0.93 (0.91–0.96) | 0.98 (0.97–0.99) | 0.92 (0.86–0.97) | 0.90 (0.86–0.93) | 0.79 (0.72–0.86) | 0.96 (0.94–0.99) | 0.90 (0.87–0.93) | 0.97 (0.96–0.99) |
| Index Ve | 0.97 (0.95–1.00) | 0.92 (0.88–0.95) | 0.84 (0.78–0.90) | 0.99 (0.97–1.00) | 0.93 (0.91–0.96) | 0.98 (0.98–0.99) | 0.91 (0.85–0.96) | 0.90 (0.86–0.94) | 0.80 (0.72–0.87) | 0.96 (0.93–0.98) | 0.90 (0.87–0.93) | 0.98 (0.96–0.99) |
| Index VIf | 0.96 (0.92–0.99) | 0.95 (0.92–0.97) | 0.89 (0.83–0.94) | 0.98 (0.96–1.00) | 0.95 (0.93–0.97) | 0.99 (0.98–0.99) | 0.90 (0.84–0.96) | 0.95 (0.92–0.98) | 0.88 (0.82–0.94) | 0.96 (0.93–0.98) | 0.93 (0.91–0.96) | 0.98 (0.96–0.99) |
| Index VIIg | 0.96 (0.92–0.99) | 0.95 (0.92–0.97) | 0.89 (0.83–0.94) | 0.98 (0.96–1.00) | 0.95 (0.93–0.97) | 0.99 (0.98–0.99) | 0.90 (0.84–0.96) | 0.95 (0.92–0.98) | 0.88 (0.82–0.94) | 0.96 (0.93–0.98) | 0.93 (0.91–0.96) | 0.98 (0.96–0.99) |
| Index VIIIh | 0.96 (0.92–0.99) | 0.94 (0.91–0.97) | 0.88 (0.82–0.93) | 0.98 (0.96–1.00) | 0.94 (0.92–0.97) | 0.99 (0.98–0.99) | 0.90 (0.84–0.96) | 0.94 (0.91–0.97) | 0.87 (0.81–0.94) | 0.96 (0.93–0.98) | 0.93 (0.90–0.96) | 0.98 (0.96–0.99) |
CI confidence interval, PPV positive predictive value, NPV negative predictive value, AUC area under the receiver operating characteristics (ROC) curve
aCalculated as (0.90 × miR-4736) + (0.55 × miR-6836-3p) – 11.3
bCalculated as (0.89 × miR-4736) + (0.54 × miR-6836-3p) + (0.043 × miR-4281) – 11.6
cCalculated as (1.00 × miR-4736) + (0.58 × miR-6836-3p) – (1.01 × miR-4281) + (0.91 × miR-762) – 12.5
dCalculated as (0.84 × miR-4736) + (0.49 × miR-6836-3p) – (1.30 × miR-4281) + (1.26 × miR-762) + (0.43 × miR-658) – 14.8
eCalculated as (0.86 × miR-4736) + (0.45 × miR-6836-3p) – (1.13 × miR-4281) + (1.34 × miR-762) + (0.58 × miR-658) – (0.25 × miR-4649-5p) – 16.0
fCalculated as (0.87 × miR-4736) + (0.52 × miR-6836-3p) – (1.14 × miR-4281) + (1.31 × miR-762) + (0.59 × miR-658) – (0.22 × miR-4649-5p) – (0.15 × miR-4665-3p) – 15.9
gCalculated as (0.87 × miR-4736) + (0.54 × miR-6836-3p) – (1.12 × miR-4281) + (1.28 × miR-762) + (0.59 × miR-658) – (0.20 × miR-4649-5p) – (0.15 × miR-4665-3p) – (0.035 × miR-663b) – 15.8
hCalculated as (0.87 × miR-4736) + (0.55 × miR-6836-3p) – (1.11 × miR-4281) + (1.29 × miR-762) + (0.60 × miR-658) – (0.18 × miR-4649-5p) – (0.14 × miR-4665-3p) – (0.038 × miR-663b) – (0.034 × miR-4258) – 16.1