Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Mar 21;9:4987. doi: 10.1038/s41598-019-41092-6

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Influence of the platinum nanoparticles (PtNPs) on ICR-191 mutagenic activity in tested eukaryotic cell lines: (A) comparison of the cell viability of HaCaT and MelJuSo cell lines incubated for 72 h in a presence of ICR-191 (4.57–450 µM), based on alamarBlue assay. Data are expressed as the mean ± standard deviation and (B) comparison of the cell viability of HaCaT and MelJuSo cell lines incubated for 72 h in a presence of PtNPs (0.2–40 µL/mL), based on alamarBlue assay. Data are expressed as the mean ± standard deviation and (C) comparison of the cell viability of HaCaT and MelJuSo cell lines incubated for 72 h in a mixture of ICR-191 (45.7 µM) and PtNPs (0.2–40 µL/mL), based on alamarBlue assay. Data are expressed as the mean ± standard deviation, and (D) confocal microscopy live analysis of the impact of platinum nanoparticles (PtNPs) on ICR-191 fluorescence in the HaCaT and MelJuSo cell lines. Cells were treated with 45.7 µM ICR-191; treated with 45.7 µM ICR-191 and 3 ng/mL PtNPs mixture, or preincubated with 3 ng/mL PtNPs and subsequently treated with 45.7 µM ICR-191 (PtNPs preincubation). Time of incubation in the presence of ICR-191 indicated above particular panels. *Values significantly different from the amount of alamarBlue reduced by untreated control cells (p < α, α = 0.05).